Curiosidades sobre Anticorpos

Tipo
Marca
Indicação Aprovada
Empresa Comercializadora
Ano de Aprovação

Murine
Orthoclone OKT3
Allograft rejection
Johnson & Johnson
June 1986

Chimeric
ReoPro
PTCA adjunct
Lilly
December 1994

Chimeric
Rituxan
Non-Hodgkin's lymphoma
Genentech
November 1997

Chimeric
Simulect
Organ rejection prophylaxis
Novartis
May 1998

Chimeric
Remicade
Rheumatoid arthritis,Crohn's disease
Johnson & Johnson
August 1998

CDR-grafted
Zenapax
Organ rejection prophylaxis
Roche
December 1997

CDR-grafted
Synagis
Respiratory syncytial virus (RSV)
Medimmune
June 1998

CDR-grafted
Herceptin
Metastatic breast cancer
Genentech
September 1998

CDR-grafted
Mylotarg
Acute myeloid leukemia
Wyeth
May 2000

CDR-grafted
Campath
Chronic lymphocytic leukemia
Millennium
July 2001

MurineRadiolabeled
Zevalin
Non-Hodgkin's Lymphoma (relapsed or refractory low-grade, follicular, or transformed B cell)
IDEC Pharmaceuticals and Schering AG
March 2002

Phage Display
Humira
Rheumatoid arthritis
Abbott Laboratories
December 2002

CDR-grafted
Xolair
Moderate to severe persistent asthma
Genentech and Novartis
June 2003

MurineRadiolabeled
Bexxar
CD20 positive, follicular, Non-Hodgkin's Lymphoma (NHL)
Corixa and GlaxoSmithKline
June 2003

CDR-grafted
Raptiva
Chronic moderate-to-severe psoriasis
Genentech and Xoma
October 2003

Chimeric
Erbitux
Colorectal cancer
Imclone and Bristol-Myers Squibb
February 2004

CDR-grafted
Avastin
Colorectal cancer
Genentech
February 2004

CDR-grafted
Tysabri
Multiple sclerosis
Biogen-Idec and Elan
November 2004

CDR-grafted
Lucentis (ranibizumab)
Wet age-related macular degeneration
Genentech
June 2006

Transgenic
Vectibix (panitumumab)
Colorectal cancer
Amgen / Abgenix
September 2006

CDR-grafted
Soliris (eculizumab)
Paroxysmal nocturnal hemoglobinuria
Alexion
March 2007